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KMID : 0613820090190091245
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Journal of Life Science
2009 Volume.19 No. 9 p.1245 ~ p.1250
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Evaluation of Antimicrobial, Antithrombin, and Antioxidant Activity of Fritillaria thunbergii Miquel
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Shin Yong-Kyu
Jang Han-Su
Kim Jee-In
Sohn Ho-Yong
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Abstract
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Beimu (Fritillaria thunbergii Miquel), a bulbous plant of Liliaceae found in Korea, Japan and China, has been used as an antitussive and expectorant agent, and is also useful in alleviating stonsillitis and bronchiolitis. Most researches have been focused on micropropagation and plant regeneration, component analysis, and dormancy relieving of beimu. Reports regarding the biological activity of beimu, such as anti-Helicobacter pyroli or platelet aggregation inhibition activity, are few and not widely available. In this study, methanol extract and its organic solvent fractions were prepared from Fritillaria thunbergii Miquel and their antimicrobial, antithrombin, and antioxidant activities were evaluated, respectively. The methanol extract contained lots of water- soluble materials (58.98%) and hexane-soluble oils (14.85%). The ethylacetate and butanol fraction at 500 ㎍/disc concentration showed strong antibacterial activity against tested bacteria, except Escherichia coli. Antifungal activity was not observed in methanol extract and its fractions. The hexane, ethylacetate and butanol fractions showed strong antithrombin activity at 4.8 ㎎/㎖ concentration. Especially, the ethylacetate fraction showed 95.4 sec of thrombin time at a concentration of 1.2 ㎎/㎖, which is comparable to aspirin, a widely used antithrombosis agent. For antioxidation activity, the ethylacetate and butanol fraction showed good 1,1-diphenyl-2-picryl hydrazyl scavenging activity (IC?? of 344∼368 ㎍/㎖). In superoxide dismutase-like activity and reducing power, the fractions showed 20∼25% of vitamin C, and 51∼54% of butyl hydroxytoluene, respectively.
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KEYWORD
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Antimicrobial, antioxidant, antithrombosis, Fritillaria thunbergii Miquel
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